Phage was one of the five Life Foundation Symbiotes that were forcefully spawned from the Venom symbiote.

When it was trapped after his host was killed, it was merged with the other Life Foundation's symbiotes (except Scream), to create a new symbiote called Hybrid, which bonded to Scott Washington.

After Washington was killed by Eddie Brock, his symbiote was found by the U.S. army and was was defused into Lasher, Riot, Phage and Agony once more.

Each of the symbiotes was given to each member of the Mercury Team. Apparently, the defusion, or its near death experience, caused each symbiote to be weaker, not being able to fully bond to the host.

The members of the Mercury Team helped Spider-Man, the new Venom and Scorn to battle Carnage, who was taking over the city of Doverton, Colorado.